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The Startup Surge: Business Formation Starts to Slow in the First Half of 2022 – Economic Innovation Group

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By Daniel Newman
Early-stage business activity in the United States remained healthy in the first half of 2022 despite surging and persistent inflation. The number of business applications over the first half of this year came in well above pre-pandemic levels, although the pace has slowed from the record-breaking levels seen in 2021. More than 817,000 applications were filed to form new businesses likely to hire employees in the first half of 2022, based on the latest data release of the Census Bureau’s Business Formation Statistics. Likely employer businesses (labeled by Census as “high propensity applications”) are a subset of total business applications capturing those most likely to hire employees if and when a business becomes operational. 
Quality new business applications are up nearly one-quarter so far this year relative to before the pandemic
As a result of the historically fast pace, applications were 23 percent higher compared to a pre-pandemic baseline covering the first six months of 2019, but that figure was down by a modest 11 percent relative to the first half of 2021, which ultimately finished with the largest annual increase on record. When including applications from nonemployer businesses, the total number of filings is up by 44 percent from before the pandemic and shows a similarly-sized drop off relative to 2021. 

The ongoing surge in new business formation began to take off in the middle of 2020 and continues to to show strength even in the face of inflationary pressures — an added challenge for new firms during a time when their financial positions can be most precarious. Inflation pushes up the prices of vital business inputs like raw materials and the cost of labor, which can lead to tighter profit margins if business owners are unable to raise prices along with costs. Now as the Federal Reserve forges ahead with interest rate increases to address inflation, it can also become more difficult to qualify for and afford loans, further challenging the ability of entrepreneurs to navigate the startup environment. However, this crop of entrepreneurs may be less reliant on borrowing — and therefore less exposed to monetary tightening — than most historical comparison groups, since many launched off of record high asset valuations and substantial pandemic-related fiscal support from the federal government. 
Even so, the latest monthly survey from the National Federation of Independent Business (NFIB) indicated inflation was the top concern among 34 percent of small businesses, reaching the highest share in more than four decades. The survey also found that respondents’ expectations on the business environment improving over the next six months reached the lowest level in the survey’s 48-year history — a troubling sign for potential entrepreneurs looking to start a business this year. One aspect weighing on these business owners is likely the uncertainty over how long high levels of inflation will continue to persist and when prices and costs will return to relative stability in the long-run. In addition to inflation, many businesses have had difficulty finding important business inputs given supply shortages in a range of industries, as nearly half of small businesses were experiencing domestic supplier delays earlier this year. 
Pandemic frontline industries continue to lead the surge in applications, but their relative dominance is shrinking
The shock of the pandemic appears to have caused significant restructuring of certain industries and a realignment of some relationships between businesses and customers. The new business surge remains broad-based across most industry sectors, as applications for new likely employer businesses through June were up across all but a few major industries relative to the first six months of 2019. Among the ten industries with the greatest number of likely employer applications, those with the largest surges emerged in several areas of the economy most affected by the changing preferences and habits of consumers over the course of the pandemic: transportation and warehousing (+53 percent), accommodation and food services (+52 percent), health care and social assistance (+36 percent), and retail trade (+31 percent).

While this year’s modest slowdown is prevalent across industries, the pace of applications has noticeably cooled in several of those sectors that are leading the new application surge. Among the ten largest industries by applications, likely employer filings have come down the most in the retail trade (-18 percent), food and accommodation services (-16 percent), and transportation and warehousing (-13 percent) sectors. As the economy continues to adjust to a new normal — and in some ways revert back to pre-pandemic norms — these industries that had the greatest incentives to innovate and fill the economic void are entering a new phase that more closely resembles the economic environment of 2019 with less uncertainty than in 2020 and 2021. 
Many Southern states are hotspots of business formation
Every state in the country has recorded an increase in likely employer business applications, but similar to the way in which some industries have pulled ahead more than others, so too have some states. While the biggest gains have been in Wyoming (+85 percent) and Delaware (+76 percent) — likely due to issues related to taxation and incorporation laws that lead many businesses to file applications there — a handful of states in ​​the South posted significant increases of at least 50 percent: Mississippi (+76 percent), Alabama (+53 percent), and South Carolina (+52 percent). The South has also seen the largest increase in the number of business establishments, or actively operating business locations, since the pandemic began

But filings have begun to slow in the first half of this year relative to last, as all but seven states recorded fewer likely employer applications in the first half of 2022. Only New Mexico, Vermont, Wyoming, Alaska, South Dakota, Montana, and Delaware recorded more applications for businesses likely to hire employees by the midpoint of this year relative to last.
The continued surge is a real boost to U.S. entrepreneurship
It has become increasingly clear that the pandemic delivered a much-needed positive shock to the rate at which Americans launch new enterprises. A healthy rate of new business formation signals a competitive and dynamic marketplace with low barriers to entry that allow new firms to enter and compete—raising quality, lowering prices, and spurring further innovation. The lack of strong new business formation in the wake of the Great Recession hindered the country’s economic recovery for years, but the new enterprise environment brought on by the pandemic is shaping up quite differently. The jump in intent to form new businesses in part likely reflects a necessity to adapt in response to job losses during the downturn as well as an opportunity to fill new economic needs amid changing consumer preferences, supply chain issues, and novel circumstances brought on by the pandemic. 
Last year, applications to form new businesses—both sole proprietorships and businesses likely to hire and scale—reached unprecedented levels, with likely employer applications totaling around 1.8 million by year’s end—just about 481,000 more than in all of 2019. Even as this year looks to be slightly off the pace of 2021, it seems highly probable that total applications will still surpass that of any year before the pandemic. Yet the ultimate survival rate of young firms is low, even in the best economic circumstances, and most entrepreneurs are now facing one of the most challenging periods of inflation and supply chain disruption in decades. It will be many months before official figures emerge on how many of these expressions of entrepreneurial intent actually turn into new businesses that go on to hire workers, but research finds that there historically has been a high correlation between the number of applications and true business formation. 
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Sorry, But I Hate Cliché Party Dresses—Here's What I'm Wearing Instead – Who What Wear

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Listen, props to everyone who looks fabulous in a body-con metallic dress, but I personally never feel comfortable in tight dresses. Instead of the cliché glittery mini for holiday parties, I'm interested in experimenting with other dress silhouettes this year. Yes, I'm still into dresses that scream "festive," but I'm also interested in other styles that are year-round classics.
For instance, I'm absolutely obsessed with the pleated plissé tiered midi dress from our newest Who What Wear Collection drop. It's such an elegant silhouette, and the gold color really packs a punch for the party circuit. In case you missed it, our last plissé dress style initially sold out almost immediately, so we have a feeling this one may go quickly as well. Scroll down to shop the dress styles I'm excited to wear for the holidays. 
Tiered Dresses
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This is the kind of dress that will earn you compliments galore. I'm in love with the delicate pleats, the pretty tiers, and of course, the joyful golden hue. 
The dress also comes in this beautiful white color, which looks amazing styled with chunky gold jewelry. 
Ruched Dresses
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I love this LBD-with-a-twist. The statement puffy sleeves and fun ruching really take it to the next level. 
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This stunner of a dress can be worn with or without the belt, so it can be easily dressed up or down.
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This is a year-round classic that you can truly wear anytime, anywhere. 
Faux-Leather Dresses
Who What Wear Collection is quickly becoming known for its scrumptious vegan leather, which is super soft to the touch and incredibly chic. 
I'm also obsessed with the beautiful brown version of the dress. I'd go for a monochrome look and throw a camel coat over it. 
Subtle Cutout Dresses
This plissé dress sold out when we first dropped it, but we've brought back several sizes. What are you waiting for? 
LBD, but make it fashion. 
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This stretchy ribbed dress is so comfortable yet elegant at the same time. 
I love how this is expertly styled with knee-high boots. 
Slip Dresses
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This marble-like print is so dreamy from any angle.
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Take note: Slip dresses look fantastic when styled over a slim-fitting turtleneck sweater. 
I think this would also look great with a sheer lace top layered underneath. 
Floral Dresses
This may not scream "holiday party," but it's the kind of dress that you can wear 365 days a year and not get tired of. 
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Hurry: This fantastic dress won't be on sale forever. 
I love switching from bright florals to moody, darker versions for winter. 
Next, the 10 most popular brands at Nordstrom and exactly what I'd buy from each

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Prabath Jayasuriya Bags ICC Player Of The Month Award

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Prabath Jayasuriya

Sri Lankan spinner Prabath Jayasuriya won the International Cricket Council (ICC) Player of the Month award following a brilliant start to his international Test career.

Jayasuriya debuted against Australia in the second Test of the home series and took figures of 6/118 and 6/59 to help the Lankans level the 2-match Test series 1-1.

In the 2-match Test series against Pakistan, Jayasuriya took nine wickets in the first Test and eight wickets in the second to end with a whopping tally of 29 wickets in just three Tests.

Prabath Jayasuriya (Image Credits: Twitter)
Prabath Jayasuriya (Image Credits: Twitter)

I am delighted with this announcement, and wish to thank the fans for voting me as the ICC Men’s Player of the Month. Certainly it has been an incredible month for me, as I made the Test debut, and also got the opportunity to contribute for my team to level the Test series played against Australia and Pakistan.”

I take this opportunity to thank my fans, team-mates, coaches, family and friends for helping my journey, and thrilled with what I am experiencing at this moment in my life,” Jayasuriya said.

“A tally of 29 wickets in just three Tests is too good to be overlooked” – Irfan Pathan on Prabath Jayasuriya

Speaking about the decision, ICC voting panel member, Irfan Pathan, said Jayasuriya’s records speak for themselves and he rightfully beat the other two contenders, Jonny Bairstow and Gustav McKeon.

Being a newcomer to Test cricket and starting with two five-wicket hauls in your first match is extraordinary, and it’s all the more impressive against a team like Australia.”

Irfan Pathan
Irfan Pathan (Image Credit: Twitter)

A tally of 29 wickets in just three Tests is too good to be overlooked and for that, he is my ICC Men’s Player of the Month,” Pathan mentioned.

Also Read – We Sent Dinesh Karthik To Bat At No.5, MS Dhoni At No.7, Don’t Know If He Was Going To Win The Game From Dressing Room – Parthiv Patel On 2019 WC Semi-final

The post Prabath Jayasuriya Bags ICC Player Of The Month Award appeared first on CricketAddictor.

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The connection between WazirX-Binance: A timeline of events as they unfolded

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WazirX is currently under the spotlight for being accused by the Enforcement Directorate (ED), India’s leading law enforcement agency fighting economic crimes, of assisting instant loan app companies in laundering money
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"Instagram A Thirst Trap", Says Elon Musk, Admits He Has Secret Account

Months after moving to buy Twitter for $44 billion, Elon Musk put the deal on hold accusing the micro-blogging platform of fraud.
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Laal Singh Chaddha actor Aamir Khan breaks down as he recalls not having money for school fee due to his family debts

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Laal Singh Chaddha actor Aamir Khan remembered his childhood days when his family was in debt and he did not had money to pay fees. Aamir spoke about how he and his siblings would be late in paying school fees and how they faced hardships during their childhood days. In an interview with Humans of Bombay, Aamir spoke his heart out about his childhood and how his family was in debt. During his school days, Aamir revealed that the fee structure was 6 for the 6th standard, 7 for the 7th standard, and 8 for the 8th standard. He revealed how he along with his siblings were always late to pay their fees and after receiving one or two warnings, the principal would announce their names in the assembly. Aamir got teary-eyed as he remembered the struggle he and his siblings went through during their childhood days. Aamir is the son of film producer Tahir Hussain and his wife Zeenat Hussain. Aamir is the eldest among Faisal Khan, Farhat Khan, and Nikhat Khan. On the work front, Aamir appeared as a child actor in Yaadon Ki Baaraat and made his Bollywood debut with Qayamat Se Qayamat Tak. Aamir has been part of several films including Raakh, Dil, Raja Hindustani, Sarfarosh, Lagaan, Rang De Basanti, Taare Zameen Par, Ghajini, and many more. Aamir’s Laal Singh Chaddha is trending on the entertainment news. He will be seen next in Laal Singh Chaddha alongside Kareena Kapoor Khan, Mona Singh, and Naga Chaitanya. Helmed by Advait Chandan, Laal Singh Chaddha is the official Hindi adaptation of Forrest Gump which will release on August 11.

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Keanu Reeves to lead Hulu's series adaptation of Devil In The White City from Martin Scorsese and Leonardo DiCaprio

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Hollywood actor Keanu Reeves has been roped in to star in the long-gestating adaptation of Erik Larson’s Devil in the White City from Martin Scorsese and Leonardo DiCaprio at Disney-backed streamer Hulu.

Keanu Reeves to lead Hulu's series adaptation of Devil In The White City from Martin Scorsese and Leonardo DiCaprio

According to The Hollywood Reporter, the drama, which has been developed as a film and TV series since Leonardo DiCaprio optioned the property in 2010, has scored a formal series order at Hulu. The news was announced Thursday as part of Hulu’s virtual time before press at the Television Critics Association’s summer tour.

Based on the best-selling book by Erik Larson, Devil in the White City “tells the story of Daniel H. Burnham, a demanding but visionary architect who races to make his mark on history with the 1893 Chicago World’s Fair, and Dr. H. H. Holmes, America’s first modern serial killer and the man behind the notorious ‘Murder Castle’ built in the Fair’s shadow,” according to the official logline.

Leonardo DiCaprio planned to star in The Devil in the White City when he first acquired the rights to the film in 2010. The actor planned to play Burnham himself, with his frequent collaborator Martin Scorsese on board to direct the film. But scheduling conflicts and development difficulties ultimately delayed the project for long enough that it was retooled as a television series. Hulu has been developing the show since 2019.

Todd Field is now on board to direct the series, which is now a co-production between Paramount Television Studios and Disney’s ABC Signature. Sam Shaw is on board as writer, showrunner and exec producer. DiCaprio and his Appian Way partner, Jennifer Davisson, will executive produce alongside Martin Scorsese. Rick Yorn, Stacey Sher, Field and Mark Lafferty also executive produce the series.

Also Read: Keanu Reeves to co-author and star in his first comic book BRZRKR

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BCCI Announces Schedule For India’s 2022-23 Domestic Season

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BCCI Announces Schedule For India's 2022-23 Domestic Season

The Board of Control for Cricket in India (BCCI) has confirmed the schedule for the upcoming domestic season which will see the return of the Irani Cup, last played back in 2018-19.

As is tradition, the Duleep Trophy will set off the season and it will see six zones battle for supremacy. Following it will be the Syed Mushtaq Ali Trophy and the Vijay Hazare Trophy.

The prestigious Duleep Trophy will mark the start of a full-fledged season, which will also see a return of the Irani Cup. The Duleep Trophy (8th September-25th September) will be contested between six zones (North, South, Central, West, East and Northeast) on a knockout basis.”

Syed Mushtaq Ali Trophy Dream11 Prediction, Fantasy Cricket Tips, Dream11 Team
Syed Mushtaq Ali Trophy

The two multi-day tournaments will be followed by the Syed Mushtaq Ali Trophy and the Vijay Hazare Trophy. The two white-ball tournaments will be contested between 38 teams split into three groups of 8 teams and two groups comprising 7 teams,” the statement from BCCI read.

Elite And Plate categories are part of BCCI’s Ranji Season

The Ranji Trophy will be played in one full flow this time around, compared to the last where it was held on either side of the IPL 2022 season. The format for the trophy remains the same with 32 teams playing in the Elite Group and the top two teams qualifying from each group to the quarterfinals.

Ranji Trophy. Photo- Twitter

The Ranji Trophy, India’s premier domestic tournament, will have two categories; 1) Elite and 2) Plate. The Elite Group will comprise 32 teams and will have 4 groups of 8 teams in a home and away format with each team playing 7 matches in the league stage. The top two teams from each of the four groups will directly qualify for the quarterfinals,” the statement further read.

The Ranji season begins on December 13 with the Plate category ending on January 29 and the Elite league finishing on February 20th.

Also Read – West Indies Need Consistency And Understanding The Situation Of The Game: Phil Simmons

The post BCCI Announces Schedule For India’s 2022-23 Domestic Season appeared first on CricketAddictor.

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The Most Hated Man on the Internet: Charlotte Laws recalls how hers and daughter Kayla's lives were threatened when she shut down Hunter Moore's Is Anyone Up site

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New Netflix series The Most Hated Man on the Internet is the latest rage in OTT news, with everyone and their grandma lapping up the hot favourite docuseries, binge-watching all 3 episodes like nobody’s business, and then meeting up online for elaborate discussions, conspiracy theories and conjecture of where is Hunter Moore, the eponymous The Most Hated Man on the Internet, and what he’s up to these days after his notorious Is Anyone Up site got shut down, largely due to the efforts of Charlotte Laws, on whose crusade the Netflix web series is largely focused, after her daughter, Kayla‘s intimate pics appeared on Moore’ revenge porn website.

When Charlotte Laws shut down Hunter Moore’s website

After being convinced that her daughter Kayla got hacked, Charlotte Laws set about to get her images removed from revenge porn site Is Anyone Up, with her daughter ending up as one of the few, somewhat fortunate victims to get their pics taken down. Chorlotte didn’t stop there as she spoke to more than forty victims of Hunter Moore, compiled evidence and convinced the FBI to shut down his IsAnyoneUp website along with the the help of anti-bullying advocate and former Marine James McGibney.

Charlotte Laws and daughter Kayla receive ominous messages

Hunter Moore didn’t seem to get the memo though after the FBI crackdown and bragged that he’ll be back with HunterMoore.tv, a more disturbing version of IsAnyoneUp, and this time addresses and maps to people’s homes would also be posted. This prompted Charlotte Laws to post his address on her Twitter account, which irked his fans no end yes, he has fans, and this is the point where the took offence leading to severe online abuse and threatening phone call to her and her daughter from Hunter Moore fans, eventually culminating in a physical showdown with one of his fans who decided to stalk their house.

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Don't force policies: Non-BJP states bring up NEP and GST

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Chief ministers of some non-BJP states on Sunday asked the Centre not to “force” its policies but to strengthen cooperative federalism and also sought a five-year extension for the compensation paid to states for revenue shortfall due to GST implementation.
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28 companies secure Sebi's clearance to float IPOs worth <span class='webrupee'>₹</span>45,000 cr in April-July

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28 companies secure Sebi’s clearance to float IPOs worth ₹45,000-cr in Apr-Jul FY23 which has already seen 11 debutantes raising over ₹33,000 crore
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World's Most Crypto-Ready Nation Hong Kong Riddled With Scams

Hong Kong has observed a 105 percent hike in crypto scams in the first six months of this year. Between January and July 2022, the crypto community of Hong Kong have collectively lost $50 million…
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Computer chips face toilet paper hoarding moment as shortage turns to glut – Reuters

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Micron Technology's solid-state drive for data center customers is presented at a product launch event in San Francisco, U.S., October 24, 2019. REUTERS/Stephen Nellis
OAKLAND, Calif., July 12 (Reuters) – A supply chain crisis triggered by the global pandemic deprived makers of PCs and smartphones to cars of computer chips needed to make their products.
All that suddenly changed over three weeks from late May to June, as high inflation, China's latest COVID lockdown, and the war in Ukraine dampened consumer spending, especially on PCs and smartphones.
Chip shortages turned into a glut in some sectors, taking Wall Street by surprise. By late June, memory chip firm Micron Technology Inc (MU.O) said it would reduce production. The market reversal caught Micron off guard, admitted Chief Business Officer Sumit Sadana. read more
As U.S. chip earnings reporting season kicks off later this month, TechInsights' chip economist Dan Hutcheson warned of more bad news following Micron's grim forecast. "Micron kind of plowed the ground, with their honesty," he said.
Worries about an industry downturn have slammed chip stocks, with the Philadelphia Semiconductor index (.SOX) tumbling 35% so far in 2022, far more than the S&P 500's (.SPX) 19% loss.
Hoarding is making it worse.
Like nervous shoppers raiding supermarket aisles for toilet paper ahead of a COVID-19 lockdown, manufacturers stockpiled computer chips during the pandemic.
Before that, "just in time" manufacturing was the norm for fiscally conservative companies, which ordered parts as close to production time as possible to avoid excess inventory, reduce warehouse capacity and cut upfront spending.
During the pandemic that shifted to what some jokingly call a "just in case" practice of stockpiling chips.
"Hoarding is a sign they think it's essential until one day they look at it and say, 'Why do I have all this inventory?'" said Hutcheson, who has been forecasting chip supply and demand for over 40 years. "It's kind of like toilet paper."
The big chip U-turn has hit unevenly across business sectors, experts said.
Big suppliers of chips to consumer electronics makers, especially low-end smartphones, will be hit hardest by the downturn, said Tristan Gerra, Baird's senior analyst for semiconductors.
Nvidia Corp (NVDA.O), the design giant whose graphic chips are used for gaming and mining cryptocurrency, could see "another shoe drop" as prices continue to fall, exacerbated by the recent cryptocurrency market crash, Gerra said.
Among those least affected by a glut are Apple Inc's suppliers such as the world's top chip factory Taiwan Semiconductor Manufacturing Co (2330.TW), said Wedbush analyst Matt Bryson. Demand remains high for Apple devices, which are more upmarket.
Chipmakers supplying automotive and data centers will also thrive, said Gerra, noting unabated demand.
"In power management, we're going gangbusters," said an executive of another global chipmaker who asked not to be identified.
However, for radio frequency chips used in smartphones, "we're seeing a pullback because of handsets," he added.
The executive's chip factory is "retooling" production lines to make more power management chips for cars and fewer RF chips, which could eventually help relieve some of the auto chip shortages, he said.
While industry executives and analysts cannot say how many excess chips are in warehouses around the world, first-quarter inventory hit a record high at key electronics manufacturing services companies, said Jefferies' analyst Mark Lipacis in a July 1 note. The previous first-quarter record was over two decades ago, right before the dotcom bubble burst.
Manufacturers may decide to use up chips in warehouses instead of buying new ones, and cancel orders, Lipacis warned.
Auto chipmakers are safe for now, some analysts said. But that may not last long.
In his September note Bernstein analyst Stacy Rasgon said automakers were ordering far more chips than they appeared to need, and that trend is continuing, he told Reuters.
That will create a problem when vehicle makers stop buying chips to use up their stockpiles.
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China should adopt autonomous vehicles in passenger transport with care, the country's Ministry of Transportation said in drafted rules to regulate the self-driving industry.
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How Do Viruses Mutate and What it Means for a Vaccine? – Pfizer

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As SARS-CoV-2 spreads around the globe, it is mutating, in other words it is acquiring genetic changes.
While the idea of “viral mutation” may sound concerning, it’s important to understand that many of these mutations are minor, and don’t have an overall impact on how fast a virus spreads or potentially how severe a viral infection might be. In fact, some mutations could make the virus less infectious.
Much of our knowledge of how viruses change to escape natural or vaccine-elicited immunity comes from observing the influenza virus and constantly updating influenza vaccines. Influenza viruses change in two main ways, antigenic drift and antigenic shift.
A comparison of the similarities and differences between coronaviruses and flu viruses may help us understand how those similarities and differences could impact potential COVID-19 vaccines.
As a virus replicates, its genes undergo random “copying errors” (i.e. genetic mutations). Over time, these genetic copying errors can, among other changes to the virus, lead to alterations in the virus’ surface proteins or antigens.1
ViralMutation_1_1200px.png
Our immune system uses these antigens to recognize and fight the virus. So, what happens if a virus mutates to evade our immune system?
In influenza viruses, genetic mutations accumulate and cause its antigens to “drift”— meaning the surface of the mutated virus looks different than the original virus.
ViralMutation_2_1200px.png
When influenza virus drifts enough, vaccines against old strains of the virus and immunity from previous influenza virus infections no longer work against the new, drifted strains. A person then becomes vulnerable to the newer, mutated flu viruses.
Antigenic drift is one of the main reasons why the flu vaccine must be reviewed and updated each year, to keep up with the influenza virus as it changes.
From what has been observed thus far regarding the genetic evolution of SARS-CoV-2, it appears that the virus is mutating relatively slowly as compared to other RNA viruses. Scientists think this is due to its ability to “proofread” newly made RNA copies.2 This proofreading function does not exist in most other RNA viruses, including influenza. Studies to date estimate that the novel coronavirus mutates at a rate approximately four times slower than the influenza virus, also known as the seasonal flu virus. Although SARS-CoV-2 is mutating, thus far, it does not seem to be drifting antigenically. It should be noted, however, that SARS-CoV-2 is a newly discovered virus infecting humans. There are still many unknowns, and our understanding of the SARS-CoV-2 virus continues to grow
ViralMutation_3_1200px.png
This relatively slow mutation rate for SARS-CoV-2 make us hopeful that investigational SARS-CoV-2 vaccine candidates will potentially have one less hurdle toward offering the ability to provide protection over a longer period of time.
Influenza viruses undergo antigenic shift, an abrupt, major change in the virus’s antigens that happens less frequently than antigenic drift.3
It occurs when two different, but related, influenza virus strains infect a host cell at the same time. Because influenza virus genomes are formed by 8 separate pieces of RNA (called “genome segments”), sometimes these viruses can “mate,” in a process called, “reassortment.” During reassortment, two influenza viruses’ genome segments can combine to make a new strain of influenza virus.
ViralMutation_4_1200px_V2.png
Reassortment results is a new subtype of virus, with antigens that are a mixture of the original strains.
When a shift happens, most people have little or no immunity against the resulting new virus (as shown by the “x” marks below). Viruses emerging as a result of antigenic shift are the ones most likely to cause pandemics.
ViralMutation_5_1200px.png
Coronaviruses do not have segmented genomes and cannot reassort. Instead, the coronavirus genome is made of a single, very long piece of RNA. However, when two coronaviruses infect the same cell, they can recombine, which is different than reassortment. In recombination, a new single RNA genome is stitched together from pieces of the two “parental” coronaviruses genomes. It’s not as efficient as reassortment, but scientists believe that coronaviruses have recombined in nature.
When this happens, scientists identify the resulting virus as a “novel coronavirus.” The generation of a novel coronavirus, although occurring by a different mechanism than antigenic shift in influenza viruses, can have a similar consequence, with pandemic spread.
Alternatively, pandemic influenza viruses can sometimes arise, not by reassortment but by “zoonosis,” when an influenza virus that infects other animals, often birds or pigs, makes the leap into humans and starts to spread.
This happens with coronaviruses, too, with new human coronaviruses,4 or genes of new human coronaviruses, coming from ancestral coronavirus es that have infected other animals, such as bats, camels or pangolins.
To date, we have seen coronaviruses act like influenza viruses in generating outbreaks and now a pandemic from processes of recombination and zoonosis generating novel human coronaviruses (resembling the antigenic shift and zoonotic origin of new human influenza virus subtypes).
Thus far, we have seen human coronaviruses mutate but not undergo antigenic drift. This is good news for coronavirus vaccines. Nevertheless, given the similarities between the behavior of influenza viruses and coronaviruses, there is ample reason to remain vigilant for the possibility of future antigenic changes in SARS-CoV-2 and to be prepared to alter a potential COVID-19 vaccine, if necessary.
References
1 CDC: How Flu Viruses Can Change: “Drift” and “Shift.”
2 “Seven months later, what we know about COVID-19 — and the pressing questions that remain.” STAT. Aug. 17, 2020. https://www.statnews.com/2020/08/17/what-we-now-know-about-covid19-and-what-questions-remain-to-be-answered/
3 CDC: How Flu Virsues Can Change: “Drift” and “Shift” https://www.cdc.gov/flu/about/viruses/change.htm
4 “Coronavirus: Where do new viruses come from?” The Conversation.  April 14, 2020. https://theconversation.com/coronavirus-where-do-new-viruses-come-from-136105
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Hospital Playlist star Jo Jung Suk to host a live show in September 2022

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South Korean actor Jo Jung Suk will reportedly host a one-man show titled 2022 Cho Jung Seok Show next month at Blue Square Mastercard Hall in central Seoul.

Hospital Playlist star Jo Jung Suk to host a live show in September 2022

According to Korean JoongAng Daily, the show will be held on September 3 at 6 p.m. and the following day at 5 p.m. For the actor’s performance on September 4, the event will be livestreamed online. The show will be held on September 3 at 6 p.m. and the following day at 5 p.m. For the actor’s performance on September 4, the event will be livestreamed online.

“Jo was beloved throughout his variety of projects from films to drama series and his singing for the soundtrack of tvN series Hospital Playlist [2020-21],” his agency Jam Entertainment told the outlet on Thursday. “We thought that his fans might like to see more of the singer’s talent in singing and dancing, which is why we thought of hosting this new project which can show all of his charms and talent.”

Jo Jung Suk is best known for his performances in dramas like The King 2 Hearts (2012), You’re the Best, Lee Soon-shin (2013), Oh My Ghost (2015), Don’t Dare to Dream (2016), Hospital Playlist franchise, as well as films The Face Reader (2013), My Love, My Bride (2014), My Annoying Brother (2016), Exit (2019).

Also Read: Park Bo Young, Yeon Woo Jin, Jang Dong Yoon and Lee Jung Eun to star in Netflix K-drama Daily Dose of Sunshine

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IND vs WI: “If I Get An Opportunity, Will Be More Than Happy To Do That” – Hardik Pandya On Taking Up Full-Time Captaincy

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Hardik Pandya

Indian all-rounder Hardik Pandya said that he would happily don the captain’s hat full-time if the management needs him to step up in the near future.

Following India’s crushing 88-run win over West Indies in the final T20I in Florida, Hardik, who is the stand-in captain in place of Rohit Sharma, said he’ll be happy to take over but for now, the focus shifts to the Asia Cup.

Very special to get a chance to lead your country. And getting that chance and getting that victory means a lot to me as captain and an individual. I was just following our captain’s roles.

Axar Patel
Axar Patel. (Photo: Twitter)

(Do you see yourself as permanent captain?) Yeah, why not? If I get an opportunity, I’ll be more than happy to do that. But for now, we have a World Cup and Asia Cup now so we need to focus on that and use our skillsets there,” Hardik said at the post-match presentation ceremony.

Hardik Pandya on what is working for the Indian team

The Men in Blue are on a roll, having defeated England in both the ODI and T20I series and repeating the same feat against the Windies. The new batch of youngsters have adopted an aggressive playstyle that is paying off dividends and Hardik spoke about the same.

The kind of talent the players have and the freedom we have. This is the new India how they are playing. They are expressing themselves well, and when you have freedom you get more dangerous.”

Shreyas Iyer And Deepak Hooda
Shreyas Iyer And Deepak Hooda

Credit to management and whole group to make that environment. They are not worried about whether they won’t get picked or whether they will get dropped,” he also noted.

Speaking about how much of the preparation for the T20 World Cup is complete, Hardik added: “Absolutely close. Just got to know how to keep getting better. Pressure and environment wise we are ready but in this sport you never stop learning.”

India took the T20I series by a 4-1 margin and will now move on to the Zimbabwe tour.

Also Read – You Cannot Write Virat Kohi Off: Brian Lara On Virat Kohli’s Poor Run With The Bat

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